The D2d Story

D2d has been a long journey that started in 2002 when the idea was conceived. We expect the outcome of the first phase of D2d to be known soon.

2018

D2d Publication: Baseline characteristics of the D2d cohort
The manuscript that describes the baseline characteristics of the D2d cohort is accepted for publication in Diabetes Care. D2d is a contemporary prediabetes cohort that...

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2017

D2d Investigators’ Meeting
The annual meeting of the D2d research team is held in Washington D.C.. On Sunday evening, as usual, Dr. Pittas presents the State of D2d, which...

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Interim analysis results are reviewed
The Data and Safety Monitoring Board (DSMB) reviews the results of the interim analysis. This is a critical point during the conduct of a clinical...

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D2d enrolls last participant
A patient from the New York Lenox Hospital site is the 2,423rd and last participant enrolled in D2d. The participant is still in D2d. Congratulations...

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2016

D2d meets enrollment goal
A patient from the Atlanta VA Medical Center site is the 2,382nd participant enrolled in D2d. The study’s recruitment goal is achieved. This is a...

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D2d Publication: Management of hemoglobin variants during hemoglobin A1c testing
When measuring HbA1c, many clinical laboratories do not report the presence of hemoglobin variants, whereas others report them only if they interfere with HbA1c measurement....

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D2d Investigators’ Meeting
The annual meeting of the D2d research team is held in Arlington, VA.. On Sunday evening, as usual, Dr. Pittas presents the State of D2d,...

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D2d enrolls 2,000th participant
A patient from the Pennington Biomedical Research Center site is the 2,000th participant enrolled in D2d. The participants is still in the study....

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2015

D2d enrolls 1,500th participant
A patient from the Northwestern University site is the 1,500th participant enrolled in D2d. The participant is still in the study....

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D2d Investigators’ Meeting
The annual meeting of the D2d research team is held in Arlington, VA. On Sunday evening, as usual, Dr. Pittas presents the State of D2d,...

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D2d enrolls 1,000th participant
A patient from the MedStar Community Clinical Research Center D2d site is the 1,000th participant enrolled in D2d. The participant is still in D2d.  ...

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2014

DSMB is pleased with recruitment progress
The DSMB meets twice a year to review the study progress. At this meeting, the DSMB is impressed with the quick turnaround in relation to...

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D2d enrolls 500th participant
A patient at the Atlanta VA Medical Center site is the 500th participant enrolled in D2d. The participant is still in D2d....

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2013

D2d enrolls 1st participant
A patient at the University of Kansas site is the 1st participant enrolled in D2d.  The participant is still in D2d....

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Press release on D2d
Tufts Medical Center (where the D2d Coordinating Center is based) and NIDDK coordinate a press release to announce the official start of D2d activities. Click...

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U.S. Government Shutdown postpones participant recruitment in D2d
The U.S. federal government enters a shutdown because neither legislation appropriating funds for fiscal year 2014 nor a continuing resolution for the interim authorization of appropriations for fiscal...

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D2d becomes the first NIDDK supported trial to use IRBShare
Obtaining IRB approval from each separate site has long been considered a major for delays in starting multi-center trials.  D2d becomes the first NIDDK-supported trial...

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Investigators’ Kick-off meeting
The first meeting of the D2d Research Group is held in Bethesda, MD on July 9-10, 2013.   Investigators and coordinators from many sites around the...

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U01 grant to conduct D2d is formally awarded
Tufts Medical Center receives the U01 cooperative agreement grant to conduct D2d. The grant is supported by NIDDK and the NIH Office of Dietary Supplements....

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The D2d DSMB inaugural meeting takes place
The inaugural meeting of the D2d Data Safety Monitoring Board (DSMB) takes place in Bethesda, MD. The core D2d team – composed of Dr. Pittas...

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2012

U01 cooperative agreement grant application undergoes scientific review
The U01 grant application undergoes a very favorable scientific peer review by NIH Special Emphasis Study Section, specifically convened to review the application. The review...

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U01 cooperative agreement grant is submitted
The D2d team submits a U01 grant application to NIH for funding to conduct D2d.  Assembling a 1,140-page grant application was a Herculean effort by...

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Progress of U34 planning phase is reviewed favorably
An External Evaluation Committee convened by NIDDK reviews the progress of the U34 planning phase. The Committee concludes that the D2d team has made excellent...

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2011

U34 planning grant is awarded
Dr. Pittas and colleagues are awarded a Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant. The NIDDK-supported grant provides support to a core team...

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2010

U34 planning grant application undergoes scientific review
The U34 grant application undergoes a highly favorable scientific peer review by a NIH Special Emphasis Study Section, specifically convened to review the application. Over...

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U34 planning grant application is submitted
Dr. Pittas and colleagues submit the Multi-Center Clinical Study Implementation Planning Cooperating Agreement (U34) grant application to NIH.  The goals of the U34 grant are...

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NIDDK allows submission of a U34 planning grant application to plan the D2d study
During the spring and early summer of 2010, the D2d concept goes through additional rounds of review within NIDDK.  In July of 2010, Dr. Pittas...

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NIDDK Large Studies Committee reviews preliminary concept of D2d
In December of 2009, Dr. Pittas approaches NIDDK and proposes the D2d study. The scientific justification for D2d and the preliminary concept of the study...

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2008

Observational study to examine the association between vitamin D status and future diabetes risk in adults with prediabetes is funded
Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)...

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2007

Observational study to examine the association between vitamin D status and future diabetes risk in women is funded
Dr. Pittas and colleagues receive funding by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH)...

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2006

The CaDDM clinical trial is funded
Based on strong preliminary data generated by Dr. Pittas and colleagues, the Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes (CaDDM) study...

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2002

Idea is conceived
The idea that vitamin D is linked to risk of developing type 2 diabetes is conceived by Dr. Pittas. In 2002, Dr. Pittas enrolled in...

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D2d | Division of Endocrinology, Diabetes and Metabolism | Tufts Medical Center | Boston MA
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