The D2d Story

2017

FEBRUARY 08, 2017

D2d enrolls last participant

The 2,423rd and last participant enrolls in D2d. Congratulations to the amazing staff for recruiting a wonderful group of dedicated participants.

2016

DECEMBER 16, 2016

D2d enrolls 2,382nd participant

A participant from the Atlanta site was the 2,382nd participant enrolled in D2d. The study’s recruitment goal is achieved.

SEPTEMBER 25, 2016

D2d Annual Meeting

The D2d Study held its fourth Annual Meeting in Arlington, VA.

JUNE 27, 2016

D2d enrolls 2,000th participant

A participant from the Nebraska site was the 2,000th participant enrolled in the D2d study. Click here to find out more about the Nebraska site.

2015

NOVEMBER 20, 2015

D2d enrolls 1,500th participant

A participant from the Florida site was the 1,500th participant enrolled in the D2d Study. Click here to find out more about the Florida site.

NOVEMBER 8, 2015

D2d Annual Meeting

The D2d Study held its third Annual Meeting in Arlington, VA. Click here to see photos from this year’s meeting.

APRIL 20, 2015

D2d enrolls 1,000th participant

A participant from the MedStar site was the 1,000th participant enrolled in the D2d Study. Click here to find out more about the MedStar site.

2014

NOVEMBER 17, 2014

D2d Annual Meeting

The second Annual Meeting was held in Crystal City, MD. Click here to see photos from the meeting

SEPTEMBER, 2014

First D2d Publication

Rationale and Design of the Vitamin D and Type 2 Diabetes (D2d) Study: A Diabetes Prevention Trial – click here to read article

JULY, 2014

D2d enrolls 500th participant

The 500th participant enrolled in the D2d Study.

2013

OCTOBER 15, 2013

Recruitment begins

D2d sites across are prescreening for people at risk for diabetes (i.e. pre-diabetes) to join D2d. For recruitment activity near you, please click here.

SEPTEMBER 19, 2013

First NIDDK supported trial to use IRBShare

D2d is the first NIDDK-supported trial and only the fifth NIH-supported study to join the IRBShare pilot phase.

JULY 9-10, 2013

Investigators Kick-off meeting

The first Investigators’ Meeting is held in Bethesda, MD. D2d investigators and coordinators worked together to plan a successful study launch.

June 1, 2013

U01 cooperative agreement grant awarded

Tufts Medical Center receives the UO1 cooperative agreement grant, supported by NIDDK and ODS, to conduct D2d.

May 31, 2013

DSMB inaugural meeting

The first Data Safety Monitoring Board meeting takes place in Bethesda, MD.

2012

2012

Association between vitamin D and Diabetes Risk in the Diabetes Prevention Program, 2012

Observational studies in the Nurses Health Study.

SEPTEMBER 14, 2012

U01 cooperative agreement grant reviewed

Tufts Medical Center’s U01 grant application undergoes scientific peer review by NIH Special Emphasis Study Section.

JUNE 5, 2012

U01 cooperative agreement grant submitted

Tufts Medical Center submits a 1,140 page U01 cooperative agreement grant to NIH for funding to conduct D2d.

MARCH 30, 2012

Progress of U34 planning phase reviewed

NIDDK External Evaluation Committee reviews the progress of the U34 planning phase and recommends to proceed with U01 grant application.

2011

JULY 20, 2011

U34 implementation grant awarded

Tufts Medical Center is awarded a NIDDK-supported U34 planning grant, which provides support, NIH programmatic involvement, and technical assistance for the planning of D2d.

2010

JULY 30, 2010

U34 implementation grant submitted

Tufts Medical Center submits a U34 planning grant to NIH for supporting the activities to establish a research team, tools for data management and study design of D2d.

JULY 1, 2010

NIDDK allows submission of implementation grant application

Tufts Medical Center receives approval for the submission of a U34 planning grant for D2d.

JANUARY, 2010

NIDDK Preliminary Review of D2d

NIDDK Large Studies Committee reviews preliminary concept of the D2d study.

2010

Association between vitamin D and Diabetes Risk in Nurses Health Study, 2010

Observational studies in Nurses Health Study strongly support an association between vitamin D concentration and incident diabetes.

2009-2010

NIDDK Large Studies Committee reviews preliminary concept of D2d, 2009-2010

The preliminary concept of D2d goes through multiple internal reviews by NIDDK.

2006

2002

2006

CaDDM trial

The NIDDK/ODS-supported Calcium and Vitamin D and Diabetes Mellitus (CaDDM) trial starts in 2006. Results support a mechanistic link between vitamin D and diabetes risk.

2002

Idea is conceived, July 2002

Idea that vitamin D may be linked to type 2 diabetes is conceived.